Spa13 of Shigella flexneri has a dual role: chaperone escort and export gate-activator switch of the type III secretion system.

@article{Cherradi2014Spa13OS,
  title={Spa13 of Shigella flexneri has a dual role: chaperone escort and export gate-activator switch of the type III secretion system.},
  author={Youness Cherradi and Abderrahman Hachani and Abdelmounaa{\"i}m Allaoui},
  journal={Microbiology},
  year={2014},
  volume={160 Pt 1},
  pages={130-41}
}
The type III secretion apparatus (T3SA) is used by numerous Gram-negative pathogens to inject virulence factors into eukaryotic cells. The Shigella flexneri T3SA spans the bacterial envelope and its assembly requires the products of ~20 mxi and spa genes. Despite progress made in understanding how the T3SA is assembled, the role of several predicted soluble components, such as Spa13, remains elusive. Here, we show that the secretion defect of the spa13 mutant is associated with lack of T3SA… CONTINUE READING
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