Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos.

@article{Kawakami2004Sp8AS,
  title={Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos.},
  author={Yasuhiko Kawakami and Concepci{\'o}n Rodr{\'i}guez Esteban and Takaaki Matsui and Joaqu{\'i}n Rodr{\'i}guez-Le{\'o}n and Shigeaki Kato and Juan Carlos Izpisua Belmonte},
  journal={Development},
  year={2004},
  volume={131 19},
  pages={4763-74}
}
Initiation and maintenance of signaling centers is a key issue during embryonic development. The apical ectodermal ridge, a specialized epithelial structure and source of Fgf8, is a pivotal signaling center for limb outgrowth. We show that two closely related buttonhead-like zinc-finger transcription factors, Sp8 and Sp9, are expressed in the AER, and regulate Fgf8 expression and limb outgrowth. Embryological and genetic analyses have revealed that Sp8 and Sp9 are ectodermal targets of Fgf10… CONTINUE READING
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