Sp1 transcriptional activity is up-regulated by phosphatase 2A in dividing T lymphocytes.

Abstract

We have followed Sp1 expression in primary human T lymphocytes induced, via CD2 plus CD28 costimulation, to sustained proliferation and subsequent return to quiescence. Binding of Sp1 to wheat germ agglutinin lectin was not modified following activation, indicating that the overall glycosylation of the protein was unchanged. Sp1 underwent, instead, a major… (More)

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@article{Lacroix2002Sp1TA, title={Sp1 transcriptional activity is up-regulated by phosphatase 2A in dividing T lymphocytes.}, author={Isabelle M. E. Lacroix and Carol Lipcey and Jean Imbert and Brigitte Kahn-Perl{\`e}s}, journal={The Journal of biological chemistry}, year={2002}, volume={277 11}, pages={9598-605} }