Sp1 regulates chromatin looping between an intronic enhancer and distal promoter of the human heme oxygenase-1 gene in renal cells.

@article{Deshane2010Sp1RC,
  title={Sp1 regulates chromatin looping between an intronic enhancer and distal promoter of the human heme oxygenase-1 gene in renal cells.},
  author={Jessy S Deshane and Junghyun Kim and Subhashini Bolisetty and Thomas David Hock and Nathalie Hill-Kapturczak and Anupam Agarwal},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 22},
  pages={16476-86}
}
HO-1 (heme oxygenase-1) is an inducible microsomal enzyme that catalyzes the degradation of pro-oxidant heme. The goal of this study was to characterize a minimal enhancer region within the human HO-1 gene and delineate its role in modulating HO-1 expression by participation with its promoter elements in renal epithelial cells. Deletion analysis and site-directed mutagenesis identified a 220-bp minimal enhancer in intron 1 of the HO-1 gene, which regulates hemin-mediated HO-1 gene expression… CONTINUE READING

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