Sp1 phosphorylation regulates apoptosis via extracellular FasL-Fas engagement.

@article{Kavurma2001Sp1PR,
  title={Sp1 phosphorylation regulates apoptosis via extracellular FasL-Fas engagement.},
  author={Mary Meltem Kavurma and Fernando S. Santiago and E Bonfoco and Levon M. Khachigian},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 7},
  pages={4964-71}
}
Apoptosis of smooth muscle cells (SMC) in atherosclerotic vessels can destabilize the atheromatus plaque and result in rupture, thrombosis, and sudden death. In efforts to understand the molecular processes regulating apoptosis in this cell type, we have defined a novel mechanism involving the ubiquitously expressed transcription factor Sp1. Subtypes of SMC expressing abundant levels of Sp1 produce the death agonist, Fas ligand (FasL) and undergo greater spontaneous apoptosis. Sp1 activates the… CONTINUE READING