Sp1 phosphorylation by Erk 2 stimulates DNA binding.

@article{Merchant1999Sp1PB,
  title={Sp1 phosphorylation by Erk 2 stimulates DNA binding.},
  author={Juanita L Merchant and Min Min Du and Andrea Todisco},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={254 2},
  pages={
          454-61
        }
}
EGF stimulates gene expression through a variety of signal transduction pathways that include the ras-Erk pathway. We have shown previously that EGF receptor activation stimulates gastrin gene expression through a GC-rich element called gERE. This element binds Sp1 family members and raises the possibility that the ras-Erk signal transduction cascade may target this novel EGF responsive element. Moreover, it is known that Erk 2 is capable of phosphorylating other mitogen-inducible transcription… CONTINUE READING
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