Sp1-mediated transcription is involved in the induction of leptin by insulin-stimulated glucose metabolism.

@article{MorenoAliaga2007Sp1mediatedTI,
  title={Sp1-mediated transcription is involved in the induction of leptin by insulin-stimulated glucose metabolism.},
  author={Mar{\'i}a J Moreno-Aliaga and Michael M. Swarbrick and Silvia Lorente-Cebri{\'a}n and K L Stanhope and P. Havel and J Alfredo Mart{\'i}nez},
  journal={Journal of molecular endocrinology},
  year={2007},
  volume={38 5},
  pages={537-46}
}
We have previously demonstrated that insulin-stimulated glucose metabolism, and not insulin per se, mediates the effects of insulin to increase the transcriptional activity of the leptin promoter in adipocytes. Here, we sought to identify the specific cis-acting DNA elements required for the upregulation of leptin gene transcription in response to insulin-mediated glucose metabolism. To accomplish this, 3T3-L1 cells and primary rat adipocytes were transfected with a series of luciferase… CONTINUE READING
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