Sp1-mediated microRNA-182 expression regulates lung cancer progression

  title={Sp1-mediated microRNA-182 expression regulates lung cancer progression},
  author={W Yang and Ping-Hsin Chen and Tsung-I Hsu and T F Fu and W C Su and Hungjiun Liaw and Wen-Chang Chang and Jan-Jong Hung},
Our recent study indicated that overexpression of Sp1 enhances the proliferation of lung cancer cells, while represses metastasis. In this study, we found that the transcriptional activity of FOXO3 was increased, but its protein levels decreased following Sp1 expression. Sp1 increased expression of miR-182, which was then recruited to the 3'-untranslated region of FOXO3 mRNA to silence its translational activity. Knockdown of miR-182 inhibited lung cancer cells growth, but enhanced the invasive… CONTINUE READING
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