Sp1-like sequences mediate human caspase-3 promoter activation by p73 and cisplatin.

@article{Sudhakar2008Sp1likeSM,
  title={Sp1-like sequences mediate human caspase-3 promoter activation by p73 and cisplatin.},
  author={Cherukuri Sudhakar and Nishant Sudhir Jain and Ghanshyam Swarup},
  journal={The FEBS journal},
  year={2008},
  volume={275 9},
  pages={2200-13}
}
Caspase-3 is a cysteine protease that plays a central role in the execution of apoptosis induced by a wide variety of stimuli. However, little is known about the mechanisms involved in the regulation of caspase-3 gene transcription. This study was carried out to characterize the human caspase-3 promoter and to understand the mechanisms involved in the induction of caspase-3 gene expression in response to the anticancer drug cisplatin and p73. Caspase-3 gene expression was induced by treatment… CONTINUE READING

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