Sp1 is upregulated in human glioma, promotes MMP-2-mediated cell invasion and predicts poor clinical outcome.

@article{Guan2012Sp1IU,
  title={Sp1 is upregulated in human glioma, promotes MMP-2-mediated cell invasion and predicts poor clinical outcome.},
  author={Hongyu Guan and Junchao Cai and Nu Zhang and Jueheng Wu and Jie Yuan and Jun Li and Mengfeng Li},
  journal={International journal of cancer},
  year={2012},
  volume={130 3},
  pages={593-601}
}
Sp1, the first identified transcription factor, has been reported to be associated with the development and progression of various human cancer types. However, the clinical significance and biological role of Sp1 in glioma are less well understood. In this study, we found that the expression of Sp1 was markedly elevated in glioma cell lines and tissues. Immunohistochemistry analysis revealed that the vast majority of 222 paraffin-embedded archival glioma specimens tested displayed positive Sp1… CONTINUE READING
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Association between expression of E ar ly D et ec ti on an d D ia gn os is 600 Sp1 overexpression predicts poor outcome in human glioma

  • JC Yao, L Wang, +6 authors K. Xie
  • Int. J. Cancer: 130,
  • 2012
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