Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle.

@article{Deaton2009Sp1dependentAO,
  title={Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle.},
  author={Rebecca A. Deaton and Qiong Gan and Gary K. Owens},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2009},
  volume={296 4},
  pages={H1027-37}
}
There is clear evidence that the phenotypic modulation of smooth muscle cells (SMCs) contributes to the pathophysiology of vascular disease. Phenotypic modulation refers to the unique ability of SMCs to alter their phenotype in response to extracellular stimuli and is hallmarked by the loss of SMC marker gene expression. The transcription factor Krüppel-like factor 4 (KLF4) is a known powerful negative regulator of SMC marker gene expression that works, in part, by decreasing the expression of… CONTINUE READING
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