Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT).

@article{Kyo2000Sp1CW,
  title={Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT).},
  author={Satoru Kyo and Masahiro Takakura and Takahiro Taira and Taro Kanaya and Hiroshi Itoh and Masuo Yutsudo and Hiroyoshi Ariga and Masaki Inoue},
  journal={Nucleic acids research},
  year={2000},
  volume={28 3},
  pages={669-77}
}
Telomerase activation is thought to be a critical step in cellular immortalization and carcinogenesis. The human telomerase catalytic subunit (hTERT) is a rate limiting determinant of the enzymatic activity of human telomerase. In the previous study, we identified the proximal 181 bp core promoter responsible for transcriptional activity of the hTERT gene. To identify the regulatory factors of transcription, transient expression assays were performed using hTERT promoter reporter plasmids… CONTINUE READING
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