Sp1 and Sp3 transcription factors synergistically regulate HGF receptor gene expression in kidney.

@article{Zhang2003Sp1AS,
  title={Sp1 and Sp3 transcription factors synergistically regulate HGF receptor gene expression in kidney.},
  author={Xiang-hong Zhang and Yingjian Li and Chunsun Dai and Junwei Yang and Peter H. Mundel and Youhua Liu},
  journal={American journal of physiology. Renal physiology},
  year={2003},
  volume={284 1},
  pages={F82-94}
}
We investigated the expression pattern and underlying mechanism that controls hepatocyte growth factor (HGF) receptor (c-met) expression in normal kidney and a variety of kidney cells. Immunohistochemical staining showed widespread expression of c-met in mouse kidney, a pattern closely correlated with renal expression of Sp1 and Sp3 transcription factors. In vitro, all types of kidney cells tested expressed different levels of c-met, which was tightly proportional to the cellular abundances of… CONTINUE READING

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