Sp1 and Sp3 transcription factors mediate malondialdehyde-induced collagen alpha 1(I) gene expression in cultured hepatic stellate cells.

@article{GarcaRuiz2002Sp1AS,
  title={Sp1 and Sp3 transcription factors mediate malondialdehyde-induced collagen alpha 1(I) gene expression in cultured hepatic stellate cells.},
  author={Inmaculada Garc{\'i}a-Ruiz and Paz de la Torre and Teresa Sosa Diaz and Elena Esteban and Inmaculada Fern{\'a}ndez and Teresa Muņoz-Yag{\"u}e and Jos{\'e} Antonio Sol{\'i}s-Herruzo},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 34},
  pages={30551-8}
}
Malondialdehyde, the end product of lipid peroxidation, has been shown to stimulate collagen alpha1(I) (Col1a1) gene expression. However, mechanisms of this effect are unclear. The purpose of this study was to clarify these mechanisms. Rat hepatic stellate cells were cultured in the presence of 200 microm malondialdehyde, and the effects on collagen gene expression and the binding of nuclear proteins to the col1a1 promoter were analyzed. Malondialdehyde treatment induced an increase in the… CONTINUE READING

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