Sp1 and C/EBP are necessary to activate the lactoferrin gene promoter during myeloid differentiation.

Abstract

In this study, we sought to identify factors responsible for the positive modulation of lactoferrin (LF), a neutrophil-specific, secondary-granule protein gene. Initial reporter gene transfection assays indicated that the first 89 base pairs of the LF promoter are capable of directing myeloid-specific LF gene expression. The presence of a C/EBP site flanked… (More)

Topics

7 Figures and Tables

Slides referencing similar topics