Sp1 and AP2 enhance promoter activity of the mouse GM3-synthase gene.

@article{Xia2005Sp1AA,
  title={Sp1 and AP2 enhance promoter activity of the mouse GM3-synthase gene.},
  author={Tian Xia and Guichao Zeng and Luoyi Gao and Robert K. Yu},
  journal={Gene},
  year={2005},
  volume={351},
  pages={109-18}
}
Promoters of the glycosyltransferase genes for ganglioside synthesis are TATA-less and often have multiple binding sites for transcription factors Sp1 and AP2 in their proximal regions. However, the function of Sp1 and AP2 in the promoters has not yet been defined. Here, we cloned 5'-flanking fragments of the mouse GM3-synthase gene and assessed the promoter activity of these fragments in mouse Neuro-2a cells. This promoter is TATA-less and contains a number of potential transcription factor… CONTINUE READING

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