Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia.

@article{Liu2010Sp1NFkappaBHDACmiR29bRN,
  title={Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia.},
  author={Shujun Liu and Lai-Chu Wu and J. Pang and R. Santhanam and S. Schwind and Yue-Zhong Wu and Christopher J. Hickey and J. Yu and H. Becker and K. Maharry and M. Radmacher and C. Li and S. Whitman and A. Mishra and Nicole Stauffer and A. Eiring and R. Briesewitz and R. Baiocchi and Kenneth K. Chan and P. Paschka and M. Caligiuri and J. Byrd and C. Croce and C. Bloomfield and D. Perrotti and R. Garzon and G. Marcucci},
  journal={Cancer cell},
  year={2010},
  volume={17 4},
  pages={
          333-47
        }
}
The biologic and clinical significance of KIT overexpression that associates with KIT gain-of-function mutations occurring in subsets of acute myeloid leukemia (AML) (i.e., core binding factor AML) is unknown. Here, we show that KIT mutations lead to MYC-dependent miR-29b repression and increased levels of the miR-29b target Sp1 in KIT-driven leukemia. Sp1 enhances its own expression by participating in a NFkappaB/HDAC complex that further represses miR-29b transcription. Upregulated Sp1 then… Expand
Inhibition of EZH2 triggers the tumor suppressive miR-29b network in multiple myeloma
Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma
miR-181d/RBP2/NF-κB p65 Feedback Regulation Promotes Chronic Myeloid Leukemia Blast Crisis
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 39 REFERENCES
Histone Deacetylase 1 Can Repress Transcription by Binding to Sp1
  • Angelika Doetzlhofer, Hans Rotheneder, +5 authors Christian Seiser
  • Biology, Medicine
  • Molecular and Cellular Biology
  • 1999
Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells.
Widespread microRNA repression by Myc contributes to tumorigenesis
Inhibition of NF-κB by ZAS3, a zinc-finger protein that also binds to the κB motif
Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells.
MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation.
  • N. Felli, L. Fontana, +13 authors C. Peschle
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
...
1
2
3
4
...