Sp1, a new biomarker that identifies a subset of aggressive pancreatic ductal adenocarcinoma.

@article{Jiang2008Sp1AN,
  title={Sp1, a new biomarker that identifies a subset of aggressive pancreatic ductal adenocarcinoma.},
  author={Naomi Y. Jiang and Bruce A. Woda and Barbara F. Banner and Giles Francis Whalen and Karen A. Dresser and Di Lu},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2008},
  volume={17 7},
  pages={1648-52}
}
Pancreatic adenocarcinoma is one of the leading causes of cancer-related deaths in the United States. Sp1 is a sequence-specific DNA binding protein that is important in the transcription of a number of regulatory genes involved in cancer cell growth, differentiation, and metastasis. In this study, we investigated Sp1 expression in pancreatic ductal adenocarcinoma and its association with clinical outcome. We studied 42 patients with primary pancreatic adenocarcinoma. The expression of Sp1 in… CONTINUE READING

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