Sp/Krüppel-like transcription factors are essential for the expression of mitochondrial glycerol phosphate dehydrogenase promoter B.

@article{Hasan2002SpKrppellikeTF,
  title={Sp/Kr{\"u}ppel-like transcription factors are essential for the expression of mitochondrial glycerol phosphate dehydrogenase promoter B.},
  author={Noaman M. Hasan and Michael J. MacDonald},
  journal={Gene},
  year={2002},
  volume={296 1-2},
  pages={221-34}
}
The human mitochondrial glycerol phosphate dehydrogenase (hmGPD) is abundant in the normal pancreatic insulin cell and its level is lowered to 50% by high glucose and diabetes. Using Drosophila and INS-1 cells, we have analysed the hmGPD gene promoter B to characterize cis-elements and trans-acting factors that affect its regulation. We identified ten efficient Sp/Krüppel-like transcription-factor-binding sites in the promoter sequence. These sites include four GC-boxes (CCCGCCC at -227, -68… CONTINUE READING

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