• Corpus ID: 12489801

Soybean isoflavones inhibit estrogen-stimulated gene expression in mouse uteri.

  title={Soybean isoflavones inhibit estrogen-stimulated gene expression in mouse uteri.},
  author={Zenglin Lian and Kenji Niwa and J Gao and Keiko Tagami and K Onczi and Hideki Mori and Teruhiko Tamaya},
  journal={European journal of gynaecological oncology},
  volume={25 3},
This study was performed to examine the inhibitory effects of soybean isoflavones on estrogen-stimulated gene expression of the uteri in ovarectomized mice. Especially when compared with the inhibitory effect of genistein and daidzein as aglycosides described in our previous report, subcutaneous administration of the glycoside genistin significantly decreased the levels of estradiol-17beta (E2)-induced expressions of c-jun, interleukin (IL)-1alpha and tumor necrosis factor (TNF)-alpha mRNAs (p… 

Do soy isoflavones cause endometrial hyperplasia?

For many years, hormone replacement therapy was considered the gold standard for the symptomatic treatment of menopause, but recent findings from the Women's Health Initiative have revealed that long-term HRT may actually lead to an increase in heart disease, breast cancer and other adverse events, such as stroke.

The potential health benefits of the isoflavone glycoside genistin

This review summarizes some of the molecular impacts and prospective roles of genistin in maintaining and treatment of health disorders and could help to develop novelgenistin medicine with significant health benefits for application in the nutraceutical and pharmaceutical fields.