Soya products and serum lipids: a meta-analysis of randomised controlled trials

  title={Soya products and serum lipids: a meta-analysis of randomised controlled trials},
  author={Oluwabunmi Tokede and Temilola A Onabanjo and Alfa Ibrahim Yansane and J. Michael Gaziano and Luc Djouss{\'e}},
  journal={British Journal of Nutrition},
  pages={831 - 843}
Soya proteins and isoflavones have been reported to exert beneficial effects on the serum lipid profile. [] Key Method A detailed literature search was conducted via MEDLINE (from 2004 through February 2014), CENTRAL (The Cochrane Controlled Clinical Trials Register) and for randomised controlled trials assessing the effects of soya on the lipid profile. The primary effect measure was the difference in means of the final measurements between the intervention and control groups.
The effect of soy or isoflavones on homocysteine levels: a meta-analysis of randomised controlled trials.
  • X. Song, R. Zeng, L. Ni, C. Liu
  • Medicine
    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association
  • 2016
Soy or isoflavones were not found to be associated with a reduction in homocysteine levels, and further studies might still be needed in carefully selected populations.
Effects of Soy Protein Containing of Isoflavones and Isoflavones Extract on Plasma Lipid Profile in Postmenopausal Women as a Potential Prevention Factor in Cardiovascular Diseases: Systematic Review and Meta-Analysis of Randomized Controlled Trials
It is suggested that soy and its isoflavones can be effective in correction changes in lipid metabolism in postmenopausal women and may favorably influence in preventing cardiovascular events.
The Effect of Soybean Lunasin on Cardiometabolic Risk Factors: A Randomized Clinical Trial
Future studies should focus on a higher dosage, larger sample size, and/or longer treatment to determine the independent role of lunasin, if any, in the effect of soy on cardiometabolic risk factors.
Effects of Intake of Soy and Non-Soy Legume on Serum HDL-Cholesterol Levels
In conclusion, intake of soy was significantly associated with elevation of HDL-C; however, non-soy consumption was not associated with a significant increase of HDL.
Soy and Isoflavone Consumption and Multiple Health Outcomes: Umbrella Review of Systematic Reviews and Meta-Analyses of Observational Studies and Randomised Trials in Humans.
The results support that promote soy intake as part of a healthy diet, and suggest that Randomised controlled trials are necessary to confirm this finding.
Effects of soy consumption on metabolic parameters in patients with metabolic syndrome: A systematic review and meta-analysis
Consuming soy products in patients with MetS effectively improved lipid profile and glycemic parameters independent of affecting anthropometric measures.


Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile.
  • S. Zhan, S. Ho
  • Biology, Medicine
    The American journal of clinical nutrition
  • 2005
The strongest lowering effects of soy protein containing isoflavones on total cholesterol, LDL cholesterol, and triacylglycerol occurred within the short initial period of intervention, whereas improvements in HDL cholesterol were only observed in studies of >12 wk duration.
Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials.
Soy isoflavones significantly reduced serum total and LDL cholesterol but did not change HDL cholesterol and triacylglycerol, and soy protein that contained enriched or depleted is oflavones also significantly improved lipid profiles.
Soy Protein Effects on Serum Lipoproteins: A Quality Assessment and Meta-Analysis of Randomized, Controlled Studies
Regular consumption of 1 to 2 servings of soy protein daily has a significant favorable impact on serum lipoprotein risk factors for CHD, and parallel RCTs had significantly higher quality grades and were associated with significantly greater improvements in serum LDL-cholesterol values.
Effects of cocoa products/dark chocolate on serum lipids: a meta-analysis
Intervention with dark chocolate/cocoa products significantly reduced serum low-density lipoprotein (LDL) and total cholesterol (TC) levels and no major effects on HDL and TG in short-term intervention trials are observed.
Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in humans: a meta-analysis
Consumption of soy-associated isoflavones is not related to changes in LDL or HDL cholesterol, and the absence of a dose–response relation between soy protein intake and blood cholesterol concentrations is not explained.
Limited Lipid-Lowering Effects of Regular Consumption of Whole Soybean Foods
Regular consumption of whole soybean milk and yogurt products had no effect on plasma lipids, blood pressure or arterial compliance in at-risk subjects, despite substantially increasing isoflavone levels in blood and urine.
Meta-analysis of the effects of soy protein intake on serum lipids.
It is found that the consumption of soy protein rather than animal protein significantly decreased serum concentrations of total cholesterol, LDL cholesterol, and triglycerides without significantly affecting serum HDL cholesterol concentrations.
Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: a randomized controlled trial in humans.
This study does not support the hypothesis that isoflavonoid phytoestrogens can improve the serum lipids, at least in subjects with average serum cholesterol concentrations, and it is concluded that estrogens can lower serum LDL cholesterol and raise HDL cholesterol.