Soy lecithin supplementation alters macrophage phagocytosis and lymphocyte response to concanavalin A: a study in alloxan‐induced diabetic rats

@article{Miranda2008SoyLS,
  title={Soy lecithin supplementation alters macrophage phagocytosis and lymphocyte response to concanavalin A: a study in alloxan‐induced diabetic rats},
  author={D. T. S. Z. Miranda and V. G. Batista and F. C. C. Grando and F. M. Paula and C. A. Fel{\'i}cio and Gabriella F S Rubbo and L. C. Fernandes and R. Curi and A. Nishiyama},
  journal={Cell Biochemistry and Function},
  year={2008},
  volume={26}
}
Dietary soy lecithin supplementation decreases hyperlipidemia and influences lipid metabolism. Although this product is used by diabetic patients, there are no data about the effect of soy lecithin supplementation on the immune system. The addition of phosphatidylcholine, the main component of lecithin, to a culture of lymphocytes has been reported to alter their function. If phosphatidylcholine changes lymphocyte functions in vitro as previously shown, then it could also affect immune cells in… Expand
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References

SHOWING 1-10 OF 39 REFERENCES
Cholesterol-lowering effect of soyabean lecithin in normolipidaemic rats by stimulation of biliary lipid secretion.
TLDR
The findings suggest that the liver plays a major role in the reduction of plasma cholesterol, the increased biliary lipid being provided by both HDL and the hepatic microsomal pools of PC and cholesterol. Expand
The role of dietary choline in the beneficial effects of lecithin on the secretion of biliary lipids in rats.
TLDR
It is concluded that choline contributes to the beneficial effect of a lecithin diet on bile secretion, and is postulated that this effect may be attributed to modulation of HDL and an enhancement of the cholesterol and phospholipid pools destined for biliary secretion. Expand
Low proliferation capacity of lymphocytes from alloxan-diabetic rats: involvement of high glucose and tyrosine phosphorylation of Shc and IRS-1.
TLDR
It is concluded that the response of lymphocyte proliferation from diabetic rats to Con A and LPS stimuli is decreased but insulin was able to promote a significant proliferative effect on these cells. Expand
The addition of soybean phosphatidylcholine to triglyceride increases suppressive effects on food intake and gastric emptying in rats.
TLDR
It is demonstrated that oil containing lecithin inhibits gastric emptying and food intake, and the effects are associated in part with CCK release. Expand
Effect of soybean leci-vita product on serum lipids and fatty acid composition in patients with elevated serum cholesterol and triglyceride levels
TLDR
Added to a regular diet, soybean Leci-Vita product significantly reduced total and LDL-cholesterol and triglyceride levels and HDL cholesterol was significantly increased and phospholipid fatty acid content was more favourable as a result of 24-week treatment. Expand
Prevention by dietary (n-6) polyunsaturated phosphatidylcholines of intrahepatic cholestasis induced by cyclosporine A in animals.
TLDR
The hypothesis of a bypass process including a separate and functional actin-independent way for the non micellar and phospholipid-dependent secretion of bile lipids is advanced. Expand
Dietary soybean phosphatidylcholines lower lipidemia: mechanisms at the levels of intestine, endothelial cell, and hepato-biliary axis.
TLDR
Phosphatidylcholines provided by the soybean lecithin metabolism appear to be key molecules controlling the biodynamic exchanges of lipids and regulate homeostasis of cholesterol and fatty acids by decreasing their synthesis and promoting cholesterol oxidation into bile salts. Expand
Effects of dietary soybean lecithin on plasma lipid transport and hepatic cholesterol metabolism in rats.
TLDR
The current data on inhibition of ACAT activity and related metabolic effects by lecithin mimic the previously reported effects following drug-induced inhibition ofACAT activity, suggesting potential beneficial effects of dietary leCithin supplementation in vascular disease. Expand
Low phagocytic activity of resident peritoneal macrophages in diabetic mice: relevance to the formation of advanced glycation end products.
TLDR
It is shown that AGEs suppress phagocytosis of fluorescent microspheres by cultured macrophages, and suppression of such activity by A GEs may explain, at least in part, the increased susceptibility of diabetic patients to infection. Expand
Dietary polyenylphosphatidylcholine decreases cholesterolemia in hypercholesterolemic rabbits: role of the hepato-biliary axis.
TLDR
Results constitute promising effects of soybean phosphatidylcholine at the hepato-biliary level, in the treatment or prevention of hyperlipidemia and related atherosclerosis. Expand
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