Soy isoflavones versus placebo in the treatment of climacteric vasomotor symptoms: systematic review and meta-analysis

@article{Bolaos2010SoyIV,
  title={Soy isoflavones versus placebo in the treatment of climacteric vasomotor symptoms: systematic review and meta-analysis},
  author={Rafael Bola{\~n}os and {\'A}ngel del Castillo and Jos{\'e} Francia},
  journal={Menopause},
  year={2010},
  volume={17},
  pages={660-666}
}
Objective: The incidence of vasomotor crises during the climacterium varies in women across different populations, and phytoestrogen consumption seems to play an important role in this problem. The aim of this study was to determine whether intervention with soy (dietary, extract, or concentrate), as compared with placebo, reduces the incidence of hot flashes in climacteric women. Methods: Only published, randomized, placebo-controlled clinical trials were selected, with a 12-week duration of… 
Phytoestrogens for menopausal vasomotor symptoms.
TLDR
Some of these trials found that phytoestrogen treatments alleviated the frequency and severity of hot flushes and night sweats when compared with placebo, but many trials were small and were determined to be at high risk of bias.
Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review
TLDR
A meta-analysis examining the efficacy of phytoestrogens for the relief of menopausal symptoms found 543 potentially relevant studies identified and 15 RCTs meeting the inclusion criteria were included.
Isoflavone Supplements for Menopausal Women: A Systematic Review
TLDR
It is found that isoflavones reduce hot flashes even accounting for placebo effect, attenuate lumbar spine bone mineral density (BMD) loss, show beneficial effects on systolic blood pressure during early menopause, and improve glycemic control in vitro.
Soy-isoflavone supplementation tends to reduce menopausal symptoms in postmenopausal women
TLDR
Daily supplementation of 100 mg soy isoflavones for 12 weeks tend to decrease the incidence of menopausal symptoms in postmenopausal women.
Effects of Calci Soya Balance and Vitagnus on Menopausal Symptoms
TLDR
Both Vitagnus and Calci soya balance were effective on reduction of menopausal symptoms to a similar extent and medical community can administer each of these two drugs based on patients’ conditions and costs.
Randomized controlled trial of whole soy and isoflavone daidzein on menopausal symptoms in equol-producing Chinese postmenopausal women
TLDR
Whole soy and purified daidzein have no significant effect on alleviation of menopausal symptoms among equol-producing postmenopausal women with prehypertension.
Impact of microbiota on the use and effects of isoflavones in the relief of climacteric symptoms in menopausal women – A review
TLDR
Phytoestrogens, especially isoflavones, have many benefits in the climacteric phase, due to the similarity of their chemical structure with the hormone estradiol (E2), reducing the rate of menopause side effects and resulting in symptom relief.
Soy extracts versus hormone therapy for reduction of menopausal hot flushes: indirect comparison
TLDR
HT and soy interventions showed a significant difference in efficacy for the reduction of hot flushes in postmenopausal women when each treatment was compared with placebo, however, using indirect comparison, there is a statistically significant difference between HT and soy extracts in their effects on hot flushing.
Menopausal Symptoms: From Soy Isoflavones to Combined Soy-Exercise Interventions
Diet and physical activity affect menopausal symptoms. We aimed to review recent evidence based on clinical trials and meta-analysis on the effect of soy isoflavones on menopausal symptoms and the
Pomegranate seed oil in women with menopausal symptoms: a prospective randomized, placebo-controlled, double-blinded trial
TLDR
In postmenopausal women, PGS does not significantly reduce hot flashes within a 12-week observation period, but further studies are needed to investigate the long-term effect.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 54 REFERENCES
Soy protein and isoflavone effects on vasomotor symptoms in peri- and postmenopausal women: the Soy Estrogen Alternative Study
TLDR
It is suggested that soy protein containing 42 or 58 mg of isoflavones is no more effective than is oflavone-extracted soy protein for improving the number and severity of vasomotor symptoms in peri- and postmenopausal women.
Effects on menopausal symptoms and acceptability of isoflavone-containing soy powder dietary supplementation
TLDR
Powdered energy drinks are not commonly consumed in Australia and were poorly tolerated in this study, suggesting that other methods of isoflavone delivery may be more appropriate in this culture, in future trials.
Vasomotor Symptom Relief by Soy Isoflavone Extract Tablets in Postmenopausal Women: A Multicenter, Double‐Blind, Randomized, Placebo‐Controlled Study
TLDR
Soy isoflavone extract was effective in reducing frequency and severity of flushes and did not stimulate the endometrium, and provide an attractive addition to the choices available for relief of hot flushes.
Soy isoflavones and melatonin for the relief of climacteric symptoms: a multicenter, double-blind, randomized study.
TLDR
Present data do not show any advantage of isoflavones or melatonin over placebo for the relief of menopausal symptoms, whereas improvement of psychological symptoms was higher in the is oflavones+melatonin group than in the other three.
Isoflavone treatment for acute menopausal symptoms
TLDR
In women receiving 60 mg is oflavones daily, hot flashes and night sweats were reduced by 57% and 43%, respectively, and this short-term prospective study implies that isoflavones could be used to relieve acute menopausal symptoms.
Benefits of soy germ isoflavones in postmenopausal women with contraindication for conventional hormone replacement therapy.
TLDR
Soy germ isoflavone exerted favorable effects on vasomotor symptoms and lipid profile, showing itself to be an interesting alternative therapy for the postmenopausal women with contraindication for conventional HRT.
Effects of a standardized soy extract on hot flushes: a multicenter, double-blind, randomized, placebo-controlled study
TLDR
There is evidence to suggest that 16 weeks of treatment with soy extract can help reduce the mean number of hot flushes per 24 hours in menopausal women.
Lack of effect of isoflavonoids on the vagina and endometrium in postmenopausal women.
TLDR
Daily administration of 114 mg of isolated isoflavones for 3 months had no effect on the subjective perception of vaginal dryness or on objective findings in the vagina or endometrium, which implies safety with regard to the endometricrium.
Phytoestrogens for Treatment of Menopausal Symptoms: A Systematic Review
TLDR
The available evidence suggests that phytoestrogens available as soy foods, soy extracts, and red clover extracts do not improve hot flushes or other menopausal symptoms.
Clinical Effects of a Standardized Soy Extract in Postmenopausal Women: A Pilot Study
TLDR
SOYSELECT may be a safe and efficacious therapy for relief of hot flushes in women who refuse or have contraindications for hormone replacement therapy.
...
1
2
3
4
5
...