Soy isoflavones exert differential effects on androgen responsive genes in LNCaP human prostate cancer cells.

@article{Rice2007SoyIE,
  title={Soy isoflavones exert differential effects on androgen responsive genes in LNCaP human prostate cancer cells.},
  author={Lori Rice and Renita Handayani and Yuehua Cui and Theresa A Medrano and Von G. Samedi and Henry V Baker and Nancy J. Szabo and Charles J Rosser and Steve Goodison and Kathleen T. Shiverick},
  journal={The Journal of nutrition},
  year={2007},
  volume={137 4},
  pages={964-72}
}
The high consumption of soy isoflavones in Asian diets has been correlated to a lower incidence of clinically important cases of prostate cancer. This study characterized the effects of a soy-derived isoflavone concentrate (ISF) on growth and gene expression profiles in the LNCaP, an androgen-sensitive human prostate cancer cell line. ISF caused a dose-dependent decrease in viability (P < 0.05) and DNA synthesis (P < 0.01), as well as an accumulation of cells in G(2)/M, and G(0)/G(1) phases of… CONTINUE READING

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