Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies

  title={Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies},
  author={Jia-Yi Dong and Liqiang Qin},
  journal={Breast Cancer Research and Treatment},
Numbers of epidemiologic studies assessing soy consumption and risk of breast cancer have yielded inconsistent results. We aimed to examine the association between soy isoflavones consumption and risk of breast cancer incidence or recurrence, by conducting a meta-analysis of prospective studies. We searched for all relevant studies with a prospective design indexed in PUBMED through September 1st, 2010. Summary relative risks (RR) were calculated using fixed- or random-effects models. Pre… 

Soy consumption and breast cancer risk: four recent meta-analyses

Soy isoflavones intake was associated with a significant reduced risk of breast cancer incidence in Asian populations, but not in Western populations, and the inverse associations between soyfood, tofu, and breast cancer risk became slightly stronger when the studies published in Japanese and Chinese were added.

Isoflavone consumption and risk of breast cancer: a dose-response meta-analysis of observational studies.

Exposure to high is oflavone may be associated with a reduced breast cancer risk in Asian populations, especially in postmenopausal women, however, no significant difference in the studies of Western populations may be due to the low intake of isoflavone levels.

Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk

An inverse association was observed between soy product intake and the incidence of GI cancer for females and for males but not for males, and a meta-analysis evaluated the association between soy consumption and gastrointestinal cancer risk by searching for prospective studies in PubMed, Web of Science, EMBASE and the reference lists of the included articles.

Tofu intake is inversely associated with risk of breast cancer: A meta-analysis of observational studies

An inverse dose-response association between tofu intake and risk of breast cancer is suggested, however, owing to the limitations of case-control studies, more properly designed prospective studies are warranted to confirm this association.

Soy intake and breast cancer risk: a prospective study of 300,000 Chinese women and a dose–response meta-analysis

The CKB study demonstrated that moderate soy intake was not associated with breast cancer risk among Chinese women and Meta-analysis of prospective studies found that each 10 mg/day increment in soy isoflavone intake was associated with a 3% (95% CI 1–5%) reduced risk of breast cancer.

Soy isoflavone intake and breast cancer risk in Japan: From the Takayama study

It is suggested that soy and isoflavone intakes have a protective effect on postmenopausal breast cancer.

Study on soy isoflavone consumption and risk of breast cancer and survival.

Soy intake is associated with a significant reduced death risk of breast cancer in Chinese population, and the highest consumption significantly reduced the cancer risk compared with the lowest consumption.

A comprehensive meta‐analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations

Overall results may be promising but are inconclusive, and further prospective cohorts assessing dietary polyphenol exposure and studies using other methods to evaluate exposure are needed to confirm and determine consumption levels required to achieve health benefits.

Flavonoids, Flavonoid Subclasses and Breast Cancer Risk: A Meta-Analysis of Epidemiologic Studies

The present study suggests the intake of flavonols and flavones, but not other flavonoid subclasses or total flavonoids, is associated with a decreased risk of breast cancer, especially among post-menopausal women.

Soy products in the management of breast cancer

Overall, these studies indicate that soy foods consumed at levels comparable to those in Asian populations have no detrimental effects on risk of breast cancer recurrence and in some cases significantly reduce the risk.



Soyfood intake in the prevention of breast cancer risk in women: a meta-analysis of observational epidemiological studies.

This meta-analysis supported the hypotheses that soyfood intake may be associated with a decreased risk of breast cancer due to the isoflavones and found strong evidence for publication bias in the combination of the studies.

Epidemiology of soy exposures and breast cancer risk

The evidence to date, based largely on case–control studies, suggest that soy food intake in the amount consumed in Asian populations may have protective effects against breast cancer.

Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: the Life After Cancer Epidemiology study

Soy isoflavones consumed at levels comparable to those in Asian populations may reduce the risk of cancer recurrence in women receiving tamoxifen therapy and moreover, appears not to interfere with tamoxIFen efficacy.

Soy, isoflavones, and breast cancer risk in Japan.

In a population-based, prospective cohort study in Japan, frequent miso soup and isoflavone consumption was associated with a reduced risk of breast cancer.

Meta-analysis of soy intake and breast cancer risk.

Recommendations for high-dose isoflavone supplementation to prevent breast cancer or prevent its recurrence are premature because of potential exposure misclassification, confounding, and lack of a dose response.

Consumption of soy foods and the risk of breast cancer: findings from the Japan Collaborative Cohort (JACC) Study

This prospective study suggests that consumption of soy food has no protective effects against breast cancer, and only among postmenopausal women is this suggested.

Soyfood intake and breast cancer survival: a followup of the Shanghai Breast Cancer Study

The data suggest that soyfoods do not have an adverse effect on breast cancer survival, and the soy-survival association did not appear to vary according to XbaI or PvuII polymorphisms in ER-alpha, or C(14206)T, G(25652)A, or A(50766)G polymorphismsIn ER-beta.

Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials

Isoflavone intake does not alter breast density in post-menopausal women, but may cause a small increase in breastdensity in pre menopausal women.

Dietary phytoestrogens are not associated with risk of overall breast cancer but diets rich in coumestrol are inversely associated with risk of estrogen receptor and progesterone receptor negative breast tumors in Swedish women.

It is found that there is no association between intake of isoflavonoids or lignans and breast cancer risk, and the results could be due to chance because of the low intake.

Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from the Japan Public Health Center-based prospective study group.

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