Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer.

@article{SinghGupta2011SoyIA,
  title={Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer.},
  author={Vinita Singh-Gupta and Michael C. Joiner and L. James Runyan and Christopher K. Yunker and Fazlul H. Sarkar and Steven U. Miller and Shirish M. Gadgeel and Andre A. Konski and Gilda Gali Hillman},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2011},
  volume={6 4},
  pages={688-98}
}
INTRODUCTION Soy isoflavones sensitize cancer cells to radiation both in vitro and in vivo. To improve the effect of radiotherapy for non-small cell lung cancer, we assessed the potential of using a complementary approach with soy isoflavones. METHODS Human A549 non-small cell lung cancer cells were treated with soy isoflavones, radiation, or both and tested for cell growth. DNA double-strand breaks (DSBs) were detected by immunostaining for γ-H2AX foci. Expressions of γ-H2AX, HIF-1α, and… CONTINUE READING
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