Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBP-regulated genes in HepG2 cells.

@article{Mullen2004SoyIA,
  title={Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBP-regulated genes in HepG2 cells.},
  author={Eimear Mullen and Rachel M Brown and Timothy F. Osborne and Neil F Shay},
  journal={The Journal of nutrition},
  year={2004},
  volume={134 11},
  pages={2942-7}
}
Soy intake reduces cholesterol levels. However, both the identity of the soy component or components that contribute to this reduction and the cellular mechanism producing this reduction are unknown. Soy consists of protein, lipids, fiber, and phytochemicals including isoflavones. We propose that the isoflavone component of soy mediates this effect, at least in part, by affecting cellular sterol homeostasis. We investigated the effects of an isoflavone-containing soy extract and the individual… CONTINUE READING