Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk.

@article{Setchell2011SoyIP,
  title={Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk.},
  author={Kenneth D. R. Setchell and Nadine Maynard Brown and Xueheng Zhao and Stephanie L Lindley and James E. Heubi and Eileen C. King and Mark Messina},
  journal={The American journal of clinical nutrition},
  year={2011},
  volume={94 5},
  pages={1284-94}
}
BACKGROUND Human and animal studies have produced conflicting results with regard to the effect of soy isoflavones on breast cancer risk. This may be due to differences in isoflavone metabolism. OBJECTIVE The objective of this study was to determine whether soy isoflavone phase II metabolism differs between humans and rodents. DESIGN Circulating total and unconjugated isoflavone concentrations were determined by mass spectrometry in plasma samples from 7 separate studies: 1) in Sprague… CONTINUE READING

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