Soy and the soy isoflavone genistein promote adipose tissue development in male mice on a low-fat diet.

@article{Zanella2015SoyAT,
  title={Soy and the soy isoflavone genistein promote adipose tissue development in male mice on a low-fat diet.},
  author={Isabella Zanella and Eleonora Marrazzo and Giorgio Biasiotto and Marialetizia Penza and Annalisa Romani and Pamela Vignolini and Luigi Caimi and Diego Di Lorenzo},
  journal={European journal of nutrition},
  year={2015},
  volume={54 7},
  pages={1095-107}
}
PURPOSE Several nutrients act as phytoestrogens, being anti-adipogenic when consumed with a fat-rich diet. Their effect on a low-fat diet (LFD) background is unknown. We tested soy and genistein effects on adipose tissue in LFD-fed mice and genistein activity in the 3T3-L1 adipogenesis model. METHODS C57BL/6 J male mice were fed an 8.5% soy-supplemented LFD (SS-LFD) or a soy-free LFD (SF-LFD) for 147 days. Groups of 3-week-old (pubertal) and 6-week-old (adult) mice on the SF-LFD were also… CONTINUE READING
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