Soy and isoflavone consumption and risk of gastrointestinal cancer: a systematic review and meta-analysis

@article{Tse2014SoyAI,
  title={Soy and isoflavone consumption and risk of gastrointestinal cancer: a systematic review and meta-analysis},
  author={Genevieve Tse and Guy D. Eslick},
  journal={European Journal of Nutrition},
  year={2014},
  volume={55},
  pages={63-73}
}
PurposeEvidence suggests that soy foods have chemoprotective properties that may reduce the risk of certain cancers such as breast and prostate cancer. However, data involving gastrointestinal (GI) have been limited, and the evidence remains controversial. This study aims to determine the potential relationship between dietary soy intake and GI cancer risk with an evaluation of the effects of isoflavone as an active soy constituent.MethodsRelevant studies were identified after literature search… Expand
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References

SHOWING 1-10 OF 69 REFERENCES
Isoflavone intake and risk of gastric cancer: a population-based prospective cohort study in Japan.
TLDR
The hypothesis that higher intakes of isoflavones prevent gastric cancer in either men or women is not supported. Expand
Dietary Soy and Isoflavone Intake and Risk of Colorectal Cancer in the Japan Public Health Center–Based Prospective Study
TLDR
The findings suggest that the intake of isoflavones, miso soup, and soy food has no substantial effect on the risk of colorectal cancer in Japanese men and women. Expand
A meta-analysis of soyfoods and risk of stomach cancer: the problem of potential confounders.
  • A. Wu, D. Yang, M. Pike
  • Medicine
  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2000
TLDR
The role of soyfoods in the etiology of stomach cancer cannot be determined with confidence until the roles of potential confounders, including salt, fruit/vegetables, and other dietary factors, are more adequately adjusted for. Expand
Soy food and isoflavone intake and colorectal cancer risk: The Fukuoka Colorectal Cancer Study
TLDR
Energy-adjusted intakes of soy foods (dry weight) and isoflavones were inversely associated with colorectal cancer risk in men and postmenopausal women, but not in pre menopausal women. Expand
Dietary phytoestrogen intake is associated with reduced colorectal cancer risk.
TLDR
The finding that phytoestrogen intake may reduce colorectal cancer risk is important, because dietary intake is potentially modifiable. Expand
Soy Consumption and Colorectal Cancer Risk in Humans: A Meta-Analysis
TLDR
Consumption of soy foods may be associated with a reduction in colorectal cancer risk in women, but not in men, according to a meta-analysis of available epidemiologic studies. Expand
Soyfoods, isoflavones and risk of colonic cancer: a review of the in vitro and in vivo data.
TLDR
Soy foods and soybean components have received considerable attention of late for their potential role in reducing cancer risk, but there is, at the moment, very limited support for soy exerting a protective effect against this type of cancer. Expand
Intake of specific nonfermented soy foods may be inversely associated with risk of distal gastric cancer in a Chinese population.
TLDR
The study found no statistically significant association between nonfermented soy food intake and distal gastric cancer risk, though the data supported the hypothesis that tofu may protect against distal Gastric cancer in men and dry bean consumption may decrease the risk of gastric cancers in postmenopausal women. Expand
Isoflavones from Phytoestrogens and Gastric Cancer Risk: A Nested Case-Control Study within the Korean Multicenter Cancer Cohort
TLDR
High serum concentrations of isoflavones were associated with a decreased risk for gastric cancer, suggesting a beneficial effect of high soybean product intake for Gastric cancer risk. Expand
Flavonoids and Colorectal Cancer in Italy
TLDR
Support is provided for an inverse association of selected classes of flavonoids with colorectal cancer risk using recently published data on the composition of foods and beverages, in terms of six principal classes of Flavonoids, on dietary information collected through a validated food-frequency questionnaire. Expand
...
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