Soy and isoflavone consumption and risk of gastrointestinal cancer: a systematic review and meta-analysis

  title={Soy and isoflavone consumption and risk of gastrointestinal cancer: a systematic review and meta-analysis},
  author={Genevieve Tse and Guy D. Eslick},
  journal={European Journal of Nutrition},
  • G. TseG. Eslick
  • Published 1 February 2016
  • Medicine
  • European Journal of Nutrition
PurposeEvidence suggests that soy foods have chemoprotective properties that may reduce the risk of certain cancers such as breast and prostate cancer. However, data involving gastrointestinal (GI) have been limited, and the evidence remains controversial. This study aims to determine the potential relationship between dietary soy intake and GI cancer risk with an evaluation of the effects of isoflavone as an active soy constituent.MethodsRelevant studies were identified after literature search… 

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The hypothesis that higher intakes of isoflavones prevent gastric cancer in either men or women is not supported.

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The findings suggest that the intake of isoflavones, miso soup, and soy food has no substantial effect on the risk of colorectal cancer in Japanese men and women.

A meta-analysis of soyfoods and risk of stomach cancer: the problem of potential confounders.

  • A. WuD. YangM. Pike
  • Medicine
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2000
The role of soyfoods in the etiology of stomach cancer cannot be determined with confidence until the roles of potential confounders, including salt, fruit/vegetables, and other dietary factors, are more adequately adjusted for.

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Energy-adjusted intakes of soy foods (dry weight) and isoflavones were inversely associated with colorectal cancer risk in men and postmenopausal women, but not in pre menopausal women.

Dietary phytoestrogen intake is associated with reduced colorectal cancer risk.

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High serum concentrations of isoflavones were associated with a decreased risk for gastric cancer, suggesting a beneficial effect of high soybean product intake for Gastric cancer risk.

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