Soy Isoflavones Improve Endothelial Function in Spontaneously Hypertensive Rats in an Estrogen-Independent Manner: Role of Nitric-Oxide Synthase, Superoxide, and Cyclooxygenase Metabolites

@article{Vera2005SoyII,
  title={Soy Isoflavones Improve Endothelial Function in Spontaneously Hypertensive Rats in an Estrogen-Independent Manner: Role of Nitric-Oxide Synthase, Superoxide, and Cyclooxygenase Metabolites},
  author={R. Vera and M. Galisteo and I. Villar and M. S{\'a}nchez and A. Zarzuelo and F. Perez-Vizcaino and J. Duarte},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2005},
  volume={314},
  pages={1300 - 1309}
}
The aim of this study was to analyze the effects of the isoflavones genistein and daidzein, and the mammalian estrogen 17β-estradiol on endothelial function in isolated aortic rings from male spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). Relaxation to acetylcholine on precontracted rings was impaired and endothelium-dependent contraction to acetylcholine in aortic rings was increased in SHR compared with WKY. Aortic NADPH-stimulated \batchmode \documentclass[fleqn,10pt… Expand
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