Soy Isoflavone Supplementation for Breast Cancer Risk Reduction: A Randomized Phase II Trial

@article{Khan2012SoyIS,
  title={Soy Isoflavone Supplementation for Breast Cancer Risk Reduction: A Randomized Phase II Trial},
  author={Seema A. Khan and R. Chatterton and Nancy Michel and M. Bryk and O. Lee and D. Ivancic and R. Heinz and C. Zalles and I. Helenowski and B. Jovanovic and A. Franke and M. Bosland and J. Wang and N. Hansen and K. Bethke and Alexander Dew and M. Coomes and R. Bergan},
  journal={Cancer Prevention Research},
  year={2012},
  volume={5},
  pages={309 - 319}
}
Soy isoflavone consumption may protect against breast cancer development. We conducted a phase IIB trial of soy isoflavone supplementation to examine its effect on breast epithelial proliferation and other biomarkers in the healthy high-risk breast. One hundred and twenty-six consented women underwent a random fine-needle aspiration (rFNA); those with 4,000 or more epithelial cells were randomized to a double-blind 6-month intervention of mixed soy isoflavones (PTIG-2535) or placebo, followed… Expand

Paper Mentions

Interventional Clinical Trial
This randomized phase II trial is studying how well genistein works in preventing breast cancer in women at high risk for breast cancer. Chemoprevention is the use of certain drugs… Expand
ConditionsBreast Cancer
InterventionDrug, Other
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