Soy‐based formulas and phyto‐oestrogens: a safety profile

  title={Soy‐based formulas and phyto‐oestrogens: a safety profile},
  author={VL Miniello and Gema Rodr{\'i}guez Moro and Matteo Tarantino and Miria Natile and Luciana Granieri and Lucio Armenio},
  journal={Acta P{\ae}diatrica},
Phyto‐oestrogens are non‐steroidal plant‐derived compounds that possess oestrogenic activity and act as selective oestrogen receptor modulators (SERMs). Among the dietary oestrogens, the isoflavone class enjoy a wide‐spread distribution in most of the members of the Leguminosae family, including such prominent high‐content representatives as soybean. Phyto‐oestrogen research has grown rapidly in recent years owing to epidemiological studies suggesting that diets rich in soy may be associated… 

Soy isoflavones as safe functional ingredients.

Current data are insufficient to draw definitive conclusions regarding the use of isoflavones as an alternative to estrogen for hormone replacement in postmenopausal women, and large, long-term intervention studies examining adverse effects and disease outcomes are needed.

Health effects of soy protein and isoflavones in humans.

  • C. Xiao
  • Medicine
    The Journal of nutrition
  • 2008
Overall, existing data are inconsistent or inadequate in supporting most of the suggested health benefits of consuming soy protein or ISF.

Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis).

It is found that there is no evidence of an adverse effect of soy isoflavonoids at physiologically relevant doses within the reproductive organs of adult male macaques.

Isoflavones in urine, saliva, and blood of infants: data from a pilot study on the estrogenic activity of soy formula

The results, based on much larger numbers of infants, strongly confirm previous reports, but whether phytoestrogens in soy formula are biologically active in infants is still an open question, and plans further longitudinal studies focusing on physical and developmental findings reflecting the effects of estrogen exposure.

Functional soy products

The safety concerns such as estrogenic, anti-estrogenic effects and anti-thyroid actions of soy as well as future trends in research and development of functional soy foods have been discussed.

Transgenerational Effects of Early Exposure to Soy Isoflavones on Reproductive Health and Bone Development in CD-1 Mice

Early life exposure to soy isoflavones compromise reproductive function but confer a transgenerational benefit to bone development in CD-1 mice.

Safety of soya-based infant formulas in children

Modern SIF are evidence-based safety options to feed children requiring them and the patterns of growth, bone health and metabolic, reproductive, endocrine, immune and neurological functions are similar to those observed in children fed CMF or HM.

Hypolipidemic Effects of Soy Protein and Isoflavones in the Prevention of Non-Alcoholic Fatty Liver Disease- A Review

Inclusion of appropriate amounts of soy protein and isoflavones in the diets might be a useful approach to decrease the prevalence of NAFLD and mitigate disease burden.



Reproductive actions of phytoestrogens.

This chapter reviews the reproductive actions of phytoestrogens, comparing mechanisms of action, dose-response relationships, and human exposures, and it is likely that some humans may experience greater exposure to phy toestrogens in infancy than in any other lifestage.

Phytoestrogens in health and disease.

Evaluating the effects and hence the potential benefits and risks of phytoestrogens is a complex task; extensive documentation of the specific intracellular effects of the various phy toestrogens in different tissues, the relationships between timing and duration of exposure and disease, and results from prospective randomized studies in humans of their clinical effects are essential.

Soy Isoflavones—Benefits and Risks from Nature’s Selective Estrogen Receptor Modulators (SERMs)

  • K. Setchell
  • Medicine
    Journal of the American College of Nutrition
  • 2001
Arguments are made for considering soy isoflavones as natural selective estrogen receptor modulators (SERMs) based upon recent data of their conformational binding to estrogen receptors, and recent knowledge related to their pharmacokinetics and clinical effects is reviewed.

Dietary isoflavones: biological effects and relevance to human health.

This review focuses on the more recent studies pertinent to this field and includes, where appropriate, the landmark and historical literature that has led to the exponential increase in interest in phytoestrogens from a clinical nutrition perspective.

Neurobehavioral effects of dietary soy phytoestrogens.

In vitro bioassays of non-steroidal phytoestrogens

Naturally occurring oestrogens in foods--a review.

Indications are given of the wide range of common food plants which have been reported to possess oestrogenic (uterotropic) activity, although it is emphasized that in general further work is necessary to substantiate these claims and to confirm the identities of the biologically active principles which have in some cases been proposed.