SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis.

@article{Mu2012SoxCTF,
  title={SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis.},
  author={Lifang Mu and Lucia Berti and Giacomo Masserdotti and Marcela Covic and Theologos M. Michaelidis and Kathrin Doberauer and Katharina Merz and Frederick Rehfeld and Anja Haslinger and Michael Wegner and Elisabeth Sock and Veronique Lefebvre and Sebastien Couillard-Despres and Ludwig Aigner and Benedikt Berninger and Dieter Chichung Lie},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 9},
  pages={3067-80}
}
Neural stem cells (NSCs) generate new hippocampal dentate granule neurons throughout adulthood. The genetic programs controlling neuronal differentiation of adult NSCs are only poorly understood. Here we show that, in the adult mouse hippocampus, expression of the SoxC transcription factors Sox4 and Sox11 is initiated around the time of neuronal commitment of adult NSCs and is maintained in immature neurons. Overexpression of Sox4 and Sox11 strongly promotes in vitro neurogenesis from adult… CONTINUE READING

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References

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Showing 1-10 of 63 references

Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010
View 11 Excerpts
Highly Influenced

Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2006
View 4 Excerpts
Highly Influenced

Neurod1 is essential for the survival and maturation of adult-born neurons

Nature Neuroscience • 2009
View 7 Excerpts
Highly Influenced

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