Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma

  title={Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma},
  author={Kathleen M. Capaccione and Xuehui Hong and Katherine Malanga Morgan and Wenyu Liu and Michael J. Bishop and Lianxin Liu and Elke Katrin Markert and Malik F Deen and Christine Minerowicz and Joseph R. Bertino and Thaddeus D. Allen and Sharon R. Pine},
Sox9 has gained increasing importance both functionally and as a prognostic factor in cancer. We demonstrate a functional role for Sox9 in inducing a mesenchymal phenotype in lung ADC. We show that Sox9 mRNA and protein are overexpressed in lung ADC, particularly those with KRAS mutations. Sox9 expression correlated with the Notch target gene Hes1, and numerous other Notch pathway components. We observed that Sox9 is a potent inducer of lung cancer cell motility and invasion, and a negative… CONTINUE READING


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