Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development.

@article{Lincoln2007Sox9IR,
  title={Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development.},
  author={Joy Lincoln and Ralf Kist and Gerd Scherer and Katherine E. Yutzey},
  journal={Developmental biology},
  year={2007},
  volume={305 1},
  pages={
          120-32
        }
}
Heart valve structures derived from mesenchymal cells of the endocardial cushions (ECs) are composed of highly organized cell lineages and extracellular matrix. Sox9 is a transcription factor required for both early and late stages of cartilage formation that is also expressed in the developing valves of the heart. The requirements for Sox9 function during valvulogenesis and adult valve homeostasis in mice were examined by conditional inactivation of Sox9 using Tie2-cre and Col2a1-cre… CONTINUE READING
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