Sox9 expression in carcinogenesis and its clinical significance in intrahepatic cholangiocarcinoma

@article{Matsushima2015Sox9EI,
  title={Sox9 expression in carcinogenesis and its clinical significance in intrahepatic cholangiocarcinoma},
  author={Hajime Matsushima and Tamotsu Kuroki and Amane Kitasato and Tomohiko Adachi and Takayuki Tanaka and Masataka Hirabaru and Takanori Hirayama and Naoki Kuroshima and Masaaki Hidaka and Akihiko Soyama and Mitsuhisa Takatsuki and Na{\'o}e Kinoshita and Kazunori Sano and Noriyuki Nishida and Susumu Eguchi},
  journal={Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver},
  year={2015},
  volume={47 12},
  pages={1067-75}
}
BACKGROUND Intrahepatic cholangiocarcinomas develop through a multi-step carcinogenesis. Precancerous lesions are defined as biliary intraepithelial neoplasia. Sex determining region Y-box9 (Sox9) is required for the normal differentiation of the biliary tract. AIMS To evaluate the Sox9 expression in carcinogenesis and its correlation with clinicopathological features in intrahepatic cholangiocarcinoma. METHODS Sox9 expression in normal epithelium, biliary intraepithelial neoplasia, and… CONTINUE READING

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