Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes.

@article{Yamashita2009Sox9DP,
  title={Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes.},
  author={Satoshi Yamashita and Masataka Andoh and Hiroe Ueno-Kudoh and Tempei Sato and Shigeru Miyaki and Hiroshi Asahara},
  journal={Experimental cell research},
  year={2009},
  volume={315 13},
  pages={
          2231-40
        }
}
The transcription factor, Sry-related High Mobility Group (HMG) box containing gene 9 (Sox9), plays a critical role in cartilage development by initiating chondrogenesis and preventing the subsequent maturation process called chondrocyte hypertrophy. This suppression mechanism by Sox9 on late-stage chondrogenesis partially results from the inhibition of Runt-related transcription factor 2 (Runx2), the main activator of hypertrophic chondrocyte differentiation. However, the precise mechanism by… CONTINUE READING
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