Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea.

@article{Dabdoub2008Sox2SI,
  title={Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea.},
  author={Alain Dabdoub and Chandrakala Puligilla and Jennifer Michelle Jones and Bernd Fritzsch and Kathryn Song Eng Cheah and Larysa Halyna Pevny and Matthew William Kelley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 47},
  pages={18396-401}
}
Sox2 is a high-mobility transcription factor that is one of the earliest markers of developing inner ear prosensory domains. In humans, mutations in SOX2 cause sensorineural hearing loss and a loss of function study in mice showed that Sox2 is required for prosensory formation in the cochlea. However, the specific roles of Sox2 have not been determined. Here we illustrate a dynamic role of Sox2 as an early permissive factor in prosensory domain formation followed by a mutually antagonistic… CONTINUE READING
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Expression of Prox1 during mouse cochlear development

  • O Bermingham-McDonogh
  • J Comp Neurol
  • 2006

Regulation of cell fate in the sensory epithelia of the inner ear

  • MW Kelley
  • Nat Rev Neurosci
  • 2006

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