Sox2 modulates the function of two distinct cell lineages in mouse skin☆

@inproceedings{Lesko2013Sox2MT,
  title={Sox2 modulates the function of two distinct cell lineages in mouse skin☆},
  author={Marta H. Lesko and Ryan R Driskell and Kai Kretzschmar and Stephen J. Goldie and Fiona M Watt},
  booktitle={Developmental biology},
  year={2013}
}
In postnatal skin the transcription factor Sox2 is expressed in the dermal papilla (DP) of guard/awl/auchene hair follicles and by mechanosensory Merkel cells in the touch domes of guard hairs. To investigate the consequences of Sox2 ablation in skin we deleted Sox2 in DP cells via Blimp1Cre and in Merkel cells via K14Cre. Loss of Sox2 from the DP did not inhibit hair follicle morphogenesis or establishment of the dermis and hypodermis. However, Sox2 expression in the DP was necessary for… CONTINUE READING

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