Sox2 marks epithelial competence to generate teeth in mammals and reptiles.

@article{Juuri2013Sox2ME,
  title={Sox2 marks epithelial competence to generate teeth in mammals and reptiles.},
  author={Emma Juuri and Maria Jussila and Kerstin Seidel and Scott Holmes and Ping Kun Tony Wu and Joy M Richman and Kristiina Heikinheimo and Cheng-Ming Chuong and Katrin Arnold and Konrad Hochedlinger and Ophir D Klein and Frederic Michon and Irma Thesleff},
  journal={Development},
  year={2013},
  volume={140 7},
  pages={
          1424-32
        }
}
Tooth renewal is initiated from epithelium associated with existing teeth. The development of new teeth requires dental epithelial cells that have competence for tooth formation, but specific marker genes for these cells have not been identified. Here, we analyzed expression patterns of the transcription factor Sox2 in two different modes of successional tooth formation: tooth replacement and serial addition of primary teeth. We observed specific Sox2 expression in the dental lamina that gives… CONTINUE READING
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