Sox2 is required for olfactory pit formation and olfactory neurogenesis through BMP restriction and Hes5 upregulation

@inproceedings{Panaliappan2018Sox2IR,
  title={Sox2 is required for olfactory pit formation and olfactory neurogenesis through BMP restriction and Hes5 upregulation},
  author={Tamilarasan K Panaliappan and Walter Wittmann and Vijay K Jidigam and Sara Mercurio and Jessica Armida Bertolini and Soufien Sghari and Raj K Bose and C{\'e}dric Patthey and Silvia K Nicolis and Lena Gunhaga},
  booktitle={Development},
  year={2018}
}
The transcription factor Sox2 is necessary to maintain pluripotency of embryonic stem cells, and to regulate neural development. Neurogenesis in the vertebrate olfactory epithelium persists from embryonic stages through adulthood. The role Sox2 plays for the development of the olfactory epithelium and neurogenesis within has, however, not been determined. Here, by analysing Sox2 conditional knockout mouse embryos and chick embryos deprived of Sox2 in the olfactory epithelium using CRISPR-Cas9… CONTINUE READING