Sox2 expression in breast tumours and activation in breast cancer stem cells

@article{Leis2012Sox2EI,
  title={Sox2 expression in breast tumours and activation in breast cancer stem cells},
  author={Olatz Leis and Arrate Eguiara and Erika L{\'o}pez-Arribillaga and Mar{\'i}a Jesus Alberdi and Susana Hern{\'a}ndez-Garc{\'i}a and Kepa Elorriaga and Atanasio Pandiella and Ricardo Rezola and Angel Garcia Martin},
  journal={Oncogene},
  year={2012},
  volume={31},
  pages={1354-1365}
}
The cancer stem cell (CSC) model does not imply that tumours are generated from transformed tissue stem cells. The target of transformation could be a tissue stem cell, a progenitor cell, or a differentiated cell that acquires self-renewal ability. The observation that induced pluripotency reprogramming and cancer are related has lead to the speculation that CSCs may arise through a reprogramming-like mechanism. Expression of pluripotency genes (Oct4, Nanog and Sox2) was tested in breast… CONTINUE READING

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