Sox2 expression defines a heterogeneous population of neurosphere-forming cells in the adult murine brain.

@article{Brazel2005Sox2ED,
  title={Sox2 expression defines a heterogeneous population of neurosphere-forming cells in the adult murine brain.},
  author={Christine Y Brazel and Tobi L. Limke and Jihan K. Osborne and Takumi Miura and Jingli Cai and Larysa Halyna Pevny and Mahendra S. Rao},
  journal={Aging cell},
  year={2005},
  volume={4 4},
  pages={197-207}
}
The identification of neural stem cells (NSCs) in situ has been prevented by the inability to identify a marker consistently expressed in all adult NSCs and is thus generally accomplished using the in vitro neurosphere-forming assay. The high-mobility group transcription factor Sox2 is expressed in embryonic neural epithelial stem cells; because these cells are thought to give rise to the adult NSC population, we hypothesized that Sox2 may continue to be expressed in adult NSCs. Using Sox2:EGFP… CONTINUE READING

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