Sox2 contributes to tooth development via Wnt signaling

  title={Sox2 contributes to tooth development via Wnt signaling},
  author={M R Lee and Eun-Jung Kim and Keishi Otsu and Hidemitsu Harada and H S Jung},
  journal={Cell and Tissue Research},
The transcription factor Sox2 is a stem cell marker that dictates cell lineage. It has been shown to mark the epithelial stem cells of the continuously growing mouse incisors. Sox2 also interferes with Wnt signaling by binding to β-catenin, a central mediator of the Wnt pathway. We show that these functions of Sox2 are essential for mouse molar development… CONTINUE READING