Sox2 activates cell proliferation and differentiation in the respiratory epithelium.

  title={Sox2 activates cell proliferation and differentiation in the respiratory epithelium.},
  author={David H. Tompkins and Val{\'e}rie Besnard and Alexander Lange and Angela R. Keiser and Susan E. Wert and M. Peral de Bruno and Jeffrey A. Whitsett},
  journal={American journal of respiratory cell and molecular biology},
  volume={45 1},
Sox2, a transcription factor critical for the maintenance of embryonic stem cells and induction of pluripotent stem cells, is expressed exclusively in the conducting airway epithelium of the lung, where it is required for differentiation of nonciliated, goblet, and ciliated cells. To determine the role of Sox2 in respiratory epithelial cells, Sox2 was selectively and conditionally expressed in nonciliated airway epithelial cells and in alveolar type II cells in the adult mouse. Sox2 induced… CONTINUE READING


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