Sox17 plays a substantial role in late-stage differentiation of the extraembryonic endoderm in vitro.

@article{Shimoda2007Sox17PA,
  title={Sox17 plays a substantial role in late-stage differentiation of the extraembryonic endoderm in vitro.},
  author={Masafumi Shimoda and Masami Kanai-Azuma and Kenshiro Hara and Satsuki Miyazaki and Yoshiakira Kanai and Morito Monden and Jun-Ichi Miyazaki},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 21},
  pages={3859-69}
}
Sox17 is a Sry-related HMG-box transcription factor developmentally expressed in both the definitive endoderm and extraembryonic endoderm (ExE). Although Sox17(-/-) mouse embryos have a defective definitive gut endoderm, their developing ExE is morphologically intact. Here, we aimed to investigate the role of Sox17 in ExE development by using an in vitro differentiation system of embryonic stem cells (ESCs). Although forced Sox17 expression in ESCs did not affect ExE commitment, it facilitated… CONTINUE READING

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