Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes.

@article{Sinner2004Sox17AB,
  title={Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes.},
  author={Debora I. Sinner and Scott Rankin and Monica S Lee and Aaron M. Zorn},
  journal={Development},
  year={2004},
  volume={131 13},
  pages={3069-80}
}
Recent studies have led to a model of the molecular pathway that specifies the endoderm during vertebrate gastrulation. The HMG box transcription factor Sox17 is a key component of this pathway and is essential for endoderm formation; however, the molecular events controlled by Sox17 are largely unknown. We have identified several direct transcriptional targets of Sox17, including Foxa1 and Foxa2. We show that beta-catenin, a component of Wnt signaling pathway, physically interacts with Sox17… CONTINUE READING
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