Sox10-rtTA mouse line for tetracycline-inducible expression of transgenes in neural crest cells and oligodendrocytes.

@article{Ludwig2004Sox10rtTAML,
  title={Sox10-rtTA mouse line for tetracycline-inducible expression of transgenes in neural crest cells and oligodendrocytes.},
  author={Andreas Ludwig and Beate Schlierf and Anke Schardt and Klaus-Armin Nave and Michael Wegner},
  journal={Genesis},
  year={2004},
  volume={40 3},
  pages={171-5}
}
Using gene targeting, we inserted a high-affinity variant of the reverse tetracycline controlled transactivator (rtTA) into the genomic Sox10 locus. This rtTA transgene faithfully recapitulated Sox10 expression in the emerging neural crest, several of its derivatives, and in oligodendrocytes. It was furthermore able to induce expression of a tetracycline inducible transgenic reporter gene in a doxycycline-dependent manner. Induction was fast, with substantial reporter gene expression visible 6… CONTINUE READING

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