Sox10 regulates the development of neural crest-derived melanocytes in Xenopus.

  title={Sox10 regulates the development of neural crest-derived melanocytes in Xenopus.},
  author={Yoichiro Aoki and Natasha Saint-Germain and Michael A Gyda and Emily Magner-Fink and Young Hoon Lee and Christine Credidio and Jean-Pierre Saint-Jeannet},
  journal={Developmental biology},
  volume={259 1},
The transcription factors of the Sox family play important roles in diverse developmental processes. A number of genetic studies have established that Sox10 is a major regulator of neural crest formation. Here, we report the cloning and functional analysis of the Xenopus Sox10 gene. Sox10 mRNA accumulates during gastrulation at the lateral edges of the neural plate, in the neural crest-forming region. In this tissue, Sox10 expression is regulated by Wnt signaling and colocalizes with two major… CONTINUE READING

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